Functionalized nanofibers in the prevention of hernia formation in the scar

Registration number: 17-322851A
Provider: Ministry of Health of the Czech Republic
Solver: RNDr. Ján Sabó CSc.
Start: 01.04. 2017
End: 31.12. 2021

Hernia in the scar is one of the most common postoperative complications affecting approximately 20% of all patients after abdominal surgery. About half of the patients after hernia plastic surgery in the scar relapse within 5 years, in the case of using a hernia sifka, about a quarter. Unfortunately, even the hernia sifka is burdened by a number of unwanted side effects with a lifelong risk. A certain change was brought about by the concept of biological hernia meshes. Due to their origin, however, they lead to an immunological response of the organism and their preparation is very economically expensive. An alternative to biological materials could be biocompatible polycaprolactone nanofibers, whose structure mimics the extracellular matrix, which significantly improves the biocompatibility of the material and leads to faster tissue regeneration. It has already been verified in experiments as a material that can be used for the regeneration of the abdominal wall. The nanofibers will be further functionalized with platelet derivatives as a source of growth factors to accelerate tissue healing. The carriers will be tested in vitro and in vivo in a small animal model (rabbit).