Registration number: TA03010165
Provider: TA CR - ALFA Program
Solver: Ing. Jiří Cigler, Ph.D.
Start: 01.01. 2013
End: 31.12. 2015
Partners: VUAB Pharma a.s. – the main recipient of the subsidy, Energocentrum Plus, s.r.o. and VŠCHT in Prague
The main goal of the project is to increase the production of the antibiotic nystatin as a result of reducing the variability of yields of individual batches of the fermentation part of production. The means to achieve this goal is the proposal of knowledge management of fermentation processes as a superior control level above the classical control system. Following the analysis of the process, mathematical and physiological models are created, on the basis of which a specific knowledge management strategy will be proposed, which will bring savings on the side of input raw materials and increase the yield of the fermentation process. The proposed solution will be applied to the production of the antibiotic anystatin, while it will be easily transferable to the production of other antibiotics produced by the genus Streptomyces.
The subject matter is subject to trade secrets (§17 to 20 of the Commercial Code), but some data is edited so that it can be made public.
Project TA03010165 is solved with the financial support of TA ČR.